Search

Microbiota-neuroimmune cross talk in stress-induced visceral hypersensitivity of the bowel

Journal Article

Visceral hypersensitivity of the lower gastrointestinal tract, defined as an increased response to colorectal disten- sion, frequently prompts episodes of debilitating abdominal pain in irritable bowel syndrome (IBS). Although the pathophysiology of IBS...

Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens

Journal Article

Dendritic cells (DCs) of the cDC2 lineage initiate allergic immunity and in the dermis are marked by their expression of CD301b. CD301b⁺ dermal DCs respond to allergens encountered in vivo, but not in vitro. This suggests that another cell in the dermis...

Impaired spontaneous endocytosis of HLA-G

Journal Article

HLA-G is a class Ib (non-classical) major histocompatibility complex (MHC) protein expressed at the maternal-fetal interface that inhibits natural killer (NK) cell-mediated lysis in an allotype-independent manner. Here we report that the spontaneous...

An airway-to-brain sensory pathway mediates influenza-induced sickness

Journal Article

Pathogen infection causes a stereotyped state of sickness that involves neuronally orchestrated behavioural and physiological changes1,2. On infection, immune cells release a 'storm' of cytokines and other mediators, many of which are detected by neurons3...

Dynamics of Innate Immune Response in Bacteria-Induced Mouse Model of Pulpitis

Journal Article

INTRODUCTION: During pulpitis, as bacteria penetrate deeper into the dentin and pulp tissue, a pulpal innate immune response is initiated. However, the kinetics of the immune response, how this relates to bacterial infiltration during pulpitis and an...

Shifts in receptors during submergence of an encephalitic arbovirus

Journal Article

Western equine encephalitis virus (WEEV) is an arthropod-borne virus (arbovirus) that frequently caused major outbreaks of encephalitis in humans and horses in the early twentieth century, but the frequency of outbreaks has since decreased markedly, and...

Identification of the target self-antigens in reperfusion injury

Journal Article

Reperfusion injury (RI), a potential life-threatening disorder, represents an acute inflammatory response after periods of ischemia resulting from myocardial infarction, stroke, surgery, or trauma. The recent identification of a monoclonal natural IgM...

Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis

Journal Article

Toll receptors in Drosophila melanogaster function in morphogenesis and host defense. Mammalian orthologues of Toll, the Toll-like receptors (TLRs), have been studied extensively for their essential functions in controlling innate and adaptive immune...

The human natural killer cell immune synapse

Journal Article

Inhibitory killer Ig-like receptors (KIR) at the surface of natural killer (NK) cells induced clustering of HLA-C at the contacting surface of target cells. In this manner, inhibitory immune synapses were formed as human NK cells surveyed target cells. At...

Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia

Journal Article

Lung-innervating nociceptor sensory neurons detect noxious or harmful stimuli and consequently protect organisms by mediating coughing, pain, and bronchoconstriction. However, the role of sensory neurons in pulmonary host defense is unclear. Here, we...

MLL 5 protein forms intranuclear foci, and overexpression inhibits cell cycle progression

Journal Article

MLL5 is a mammalian trithorax group (trx-G) gene identified within chromosome band 7q22, a frequently deleted element found in cytogenetic aberrations of acute myeloid malignancies. MLL5 cDNA was linked with the FLAG and V5 tags at the N and C terminus...

Induction of antiviral interferon-stimulated genes by neuronal STING promotes the resolution of pain in mice

Journal Article

Inflammation and pain are intertwined responses to injury, infection, or chronic diseases. While acute inflammation is essential in determining pain resolution and opioid analgesia, maladaptive processes occurring during resolution can lead to the...

Filters

56 results for "Primary Research Papers"

56 results for "Primary Research Papers"

Microbiota-neuroimmune cross talk in stress-induced visceral hypersensitivity of the bowel

Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens

Impaired spontaneous endocytosis of HLA-G

An airway-to-brain sensory pathway mediates influenza-induced sickness

Dynamics of Innate Immune Response in Bacteria-Induced Mouse Model of Pulpitis

Shifts in receptors during submergence of an encephalitic arbovirus

Identification of the target self-antigens in reperfusion injury

Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis

The human natural killer cell immune synapse

Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia

MLL 5 protein forms intranuclear foci, and overexpression inhibits cell cycle progression

Induction of antiviral interferon-stimulated genes by neuronal STING promotes the resolution of pain in mice