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104 results
2024
Liwen Deng, Jacob Gillis, Isaac Chiu, and Daniel Kaplan. 2024. “Sensory Neurons: An Integrated Component of Innate Immunity”. Immunity, 57, 4, Pp. 815-31. doi:10.1016/j.immuni.2024.03.008
Liwen Deng, Jacob Gillis, Isaac Chiu, and Daniel Kaplan. 2024. “Sensory Neurons: An Integrated Component of Innate Immunity”. Immunity, 57, 4, Pp. 815-31. doi:10.1016/j.immuni.2024.03.008
The sensory nervous system possesses the ability to integrate exogenous threats and endogenous signals to mediate downstream effector functions. Sensory neurons have been shown to activate or suppress host defense and immunity against pathogens, depending...
Manon Defaye, Amyaouch Bradaia, Nasser Abdullah, Francina Agosti, Mircea Iftinca, Mélissa Delanne-Cuménal, Vanessa Soubeyre, Kristofer Svendsen, Gurveer Gill, Aye Ozmaeian, Nadine Gheziel, Jérémy Martin, Gaetan Poulen, Nicolas Lonjon, Florence Vachiery-Lahaye, Luc Bauchet, Lilian Basso, Emmanuel Bourinet, Isaac Chiu, and Christophe Altier. 2024. “Induction of Antiviral Interferon-Stimulated Genes by Neuronal STING Promotes the Resolution of Pain in Mice”. J Clin Invest, 134, 9. doi:10.1172/JCI176474
Manon Defaye, Amyaouch Bradaia, Nasser Abdullah, Francina Agosti, Mircea Iftinca, Mélissa Delanne-Cuménal, Vanessa Soubeyre, Kristofer Svendsen, Gurveer Gill, Aye Ozmaeian, Nadine Gheziel, Jérémy Martin, Gaetan Poulen, Nicolas Lonjon, Florence Vachiery-Lahaye, Luc Bauchet, Lilian Basso, Emmanuel Bourinet, Isaac Chiu, and Christophe Altier. 2024. “Induction of Antiviral Interferon-Stimulated Genes by Neuronal STING Promotes the Resolution of Pain in Mice”. J Clin Invest, 134, 9. doi:10.1172/JCI176474
Inflammation and pain are intertwined responses to injury, infection, or chronic diseases. While acute inflammation is essential in determining pain resolution and opioid analgesia, maladaptive processes occurring during resolution can lead to the...
Kara Margolis, Terez Shea-Donohue, Diana Cummings, Patricia Greenwel, Robert Lunsford, Brian Gulbransen, and Isaac Chiu. 2024. “2023 Workshop: Neuroimmune Crosstalk in the Gut - Impact on Local, Autonomic and Gut-Brain Function”. Gastroenterology, Pp. S0016-5085(24)00306. doi:10.1053/j.gastro.2024.03.023
Kara Margolis, Terez Shea-Donohue, Diana Cummings, Patricia Greenwel, Robert Lunsford, Brian Gulbransen, and Isaac Chiu. 2024. “2023 Workshop: Neuroimmune Crosstalk in the Gut - Impact on Local, Autonomic and Gut-Brain Function”. Gastroenterology, Pp. S0016-5085(24)00306. doi:10.1053/j.gastro.2024.03.023
Warakorn Kulalert, Alexandria Wells, Verena Link, Ai Ing Lim, Nicolas Bouladoux, Motoyoshi Nagai, Oliver Harrison, Olena Kamenyeva, Juraj Kabat, Michel Enamorado, Isaac Chiu, and Yasmine Belkaid. 2024. “The Neuroimmune CGRP-RAMP1 Axis Tunes Cutaneous Adaptive Immunity to the Microbiota”. Proc Natl Acad Sci U S A, 121, 11, Pp. e2322574121. doi:10.1073/pnas.2322574121
Warakorn Kulalert, Alexandria Wells, Verena Link, Ai Ing Lim, Nicolas Bouladoux, Motoyoshi Nagai, Oliver Harrison, Olena Kamenyeva, Juraj Kabat, Michel Enamorado, Isaac Chiu, and Yasmine Belkaid. 2024. “The Neuroimmune CGRP-RAMP1 Axis Tunes Cutaneous Adaptive Immunity to the Microbiota”. Proc Natl Acad Sci U S A, 121, 11, Pp. e2322574121. doi:10.1073/pnas.2322574121
The somatosensory nervous system surveils external stimuli at barrier tissues, regulating innate immune cells under infection and inflammation. The roles of sensory neurons in controlling the adaptive immune system, and more specifically immunity to the...
Lijun Qi, Michael Iskols, David Shi, Pranav Reddy, Christopher Walker, Karina Lezgiyeva, Tiphaine Voisin, Mathias Pawlak, Vijay Kuchroo, Isaac Chiu, David Ginty, and Nikhil Sharma. 2024. “A Mouse DRG Genetic Toolkit Reveals Morphological and Physiological Diversity of Somatosensory Neuron Subtypes”. Cell, 187, 6, Pp. 1508-1526.e16. doi:10.1016/j.cell.2024.02.006
Lijun Qi, Michael Iskols, David Shi, Pranav Reddy, Christopher Walker, Karina Lezgiyeva, Tiphaine Voisin, Mathias Pawlak, Vijay Kuchroo, Isaac Chiu, David Ginty, and Nikhil Sharma. 2024. “A Mouse DRG Genetic Toolkit Reveals Morphological and Physiological Diversity of Somatosensory Neuron Subtypes”. Cell, 187, 6, Pp. 1508-1526.e16. doi:10.1016/j.cell.2024.02.006
Dorsal root ganglia (DRG) somatosensory neurons detect mechanical, thermal, and chemical stimuli acting on the body. Achieving a holistic view of how different DRG neuron subtypes relay neural signals from the periphery to the CNS has been challenging...
Juan-Manuel Leyva-Castillo, Daniela Vega-Mendoza, Maria Strakosha, Liwen Deng, Samantha Choi, Kensuke Miyake, Hajime Karasuyama, Isaac Chiu, Wanda Phipatanakul, and Raif Geha. 2024. “Basophils Are Important for Development of Allergic Skin Inflammation”. J Allergy Clin Immunol, 153, 5, Pp. 1344-54. doi:10.1016/j.jaci.2024.01.022
Juan-Manuel Leyva-Castillo, Daniela Vega-Mendoza, Maria Strakosha, Liwen Deng, Samantha Choi, Kensuke Miyake, Hajime Karasuyama, Isaac Chiu, Wanda Phipatanakul, and Raif Geha. 2024. “Basophils Are Important for Development of Allergic Skin Inflammation”. J Allergy Clin Immunol, 153, 5, Pp. 1344-54. doi:10.1016/j.jaci.2024.01.022
BACKGROUND: Atopic dermatitis skin lesions exhibit increased infiltration by basophils. Basophils produce IL-4, which plays an important role in the pathogenesis of atopic dermatitis. OBJECTIVE: We sought to determine the role of basophils in a mouse...
Meng Wu, Wen Zheng, Xinyang Song, Bin Bao, Yuanyou Wang, Deepshika Ramanan, Daping Yang, Rui Liu, John Macbeth, Elyza Do, Warrison Andrade, Tiandi Yang, Hyoung-Soo Cho, Francesca Gazzaniga, Marit Ilves, Daniela Coronado, Charlotte Thompson, Saiyu Hang, Isaac Chiu, Jeffrey Moffitt, Ansel Hsiao, John Mekalanos, Christophe Benoist, and Dennis Kasper. 2024. “Gut Complement Induced by the Microbiota Combats Pathogens and Spares Commensals”. Cell, 187, 4, Pp. 897-913.e18. doi:10.1016/j.cell.2023.12.036
Meng Wu, Wen Zheng, Xinyang Song, Bin Bao, Yuanyou Wang, Deepshika Ramanan, Daping Yang, Rui Liu, John Macbeth, Elyza Do, Warrison Andrade, Tiandi Yang, Hyoung-Soo Cho, Francesca Gazzaniga, Marit Ilves, Daniela Coronado, Charlotte Thompson, Saiyu Hang, Isaac Chiu, Jeffrey Moffitt, Ansel Hsiao, John Mekalanos, Christophe Benoist, and Dennis Kasper. 2024. “Gut Complement Induced by the Microbiota Combats Pathogens and Spares Commensals”. Cell, 187, 4, Pp. 897-913.e18. doi:10.1016/j.cell.2023.12.036
Canonically, the complement system is known for its rapid response to remove microbes in the bloodstream. However, relatively little is known about a functioning complement system on intestinal mucosal surfaces. Herein, we report the local synthesis of...
2023
Liwen Deng, Flavia Costa, Kimbria Blake, Samantha Choi, Arundhasa Chandrabalan, Muhammad Saad Yousuf, Stephanie Shiers, Daniel Dubreuil, Daniela Vega-Mendoza, Corinne Rolland, Celine Deraison, Tiphaine Voisin, Michelle Bagood, Lucia Wesemann, Abigail Frey, Joseph Palumbo, Brian Wainger, Richard Gallo, Juan-Manuel Leyva-Castillo, Nathalie Vergnolle, Theodore Price, Rithwik Ramachandran, Alexander Horswill, and Isaac Chiu. 2023. “S. Aureus Drives Itch and Scratch-Induced Skin Damage through a V8 Protease-PAR1 Axis”. Cell, 186, 24, Pp. 5375-5393.e25. doi:10.1016/j.cell.2023.10.019
Liwen Deng, Flavia Costa, Kimbria Blake, Samantha Choi, Arundhasa Chandrabalan, Muhammad Saad Yousuf, Stephanie Shiers, Daniel Dubreuil, Daniela Vega-Mendoza, Corinne Rolland, Celine Deraison, Tiphaine Voisin, Michelle Bagood, Lucia Wesemann, Abigail Frey, Joseph Palumbo, Brian Wainger, Richard Gallo, Juan-Manuel Leyva-Castillo, Nathalie Vergnolle, Theodore Price, Rithwik Ramachandran, Alexander Horswill, and Isaac Chiu. 2023. “S. Aureus Drives Itch and Scratch-Induced Skin Damage through a V8 Protease-PAR1 Axis”. Cell, 186, 24, Pp. 5375-5393.e25. doi:10.1016/j.cell.2023.10.019
Itch is an unpleasant sensation that evokes a desire to scratch. The skin barrier is constantly exposed to microbes and their products. However, the role of microbes in itch generation is unknown. Here, we show that Staphylococcus aureus, a bacterial...
Ozge Erdogan, Benoit Michot, Jinya Xia, Lama Alabdulaaly, Pilar Yesares Rubi, Vivian Ha, Isaac Chiu, and Jennifer Gibbs. 2023. “Neuronal-Immune Axis Alters Pain and Sensory Afferent Damage During Dental Pulp Injury”. Pain. doi:10.1097/j.pain.0000000000003029
Ozge Erdogan, Benoit Michot, Jinya Xia, Lama Alabdulaaly, Pilar Yesares Rubi, Vivian Ha, Isaac Chiu, and Jennifer Gibbs. 2023. “Neuronal-Immune Axis Alters Pain and Sensory Afferent Damage During Dental Pulp Injury”. Pain. doi:10.1097/j.pain.0000000000003029
Dental pulp tissue is densely innervated by afferent fibers of the trigeminal ganglion. When bacteria cause dental decay near the pulpal tissue, a strong neuronal and immune response occurs, creating pulpitis, which is associated with severe pain and pulp...
Benoit Michot, Sharon Casey, Caroline Lee, Ozge Erdogan, Himanish Basu, Isaac Chiu, and Jennifer Gibbs. 2023. “Lipopolysaccharide-Induced TRPA1 Upregulation in Trigeminal Neurons Is Dependent on TLR4 and Vesicular Exocytosis”. J Neurosci, 43, 40, Pp. 6731-44. doi:10.1523/JNEUROSCI.0162-23.2023
Benoit Michot, Sharon Casey, Caroline Lee, Ozge Erdogan, Himanish Basu, Isaac Chiu, and Jennifer Gibbs. 2023. “Lipopolysaccharide-Induced TRPA1 Upregulation in Trigeminal Neurons Is Dependent on TLR4 and Vesicular Exocytosis”. J Neurosci, 43, 40, Pp. 6731-44. doi:10.1523/JNEUROSCI.0162-23.2023
Pain from bacterial infection was believed to be the consequence of inflammation induced by bacterial products. However recent studies have shown that bacterial products can directly activate sensory neurons and induce pain. The mechanisms by which...
Ozge Erdogan, Jingya Xia, Isaac Chiu, and Jennifer Gibbs. 2023. “Dynamics of Innate Immune Response in Bacteria-Induced Mouse Model of Pulpitis”. J Endod. doi:10.1016/j.joen.2023.08.019
Ozge Erdogan, Jingya Xia, Isaac Chiu, and Jennifer Gibbs. 2023. “Dynamics of Innate Immune Response in Bacteria-Induced Mouse Model of Pulpitis”. J Endod. doi:10.1016/j.joen.2023.08.019
INTRODUCTION: During pulpitis, as bacteria penetrate deeper into the dentin and pulp tissue, a pulpal innate immune response is initiated. However, the kinetics of the immune response, how this relates to bacterial infiltration during pulpitis and an...
Daping Yang, Nicole Almanzar, and Isaac Chiu. 2023. “The Role of Cellular and Molecular Neuroimmune Crosstalk in Gut Immunity”. Cell Mol Immunol. doi:10.1038/s41423-023-01054-5
Daping Yang, Nicole Almanzar, and Isaac Chiu. 2023. “The Role of Cellular and Molecular Neuroimmune Crosstalk in Gut Immunity”. Cell Mol Immunol. doi:10.1038/s41423-023-01054-5
The gastrointestinal tract is densely innervated by the peripheral nervous system and populated by the immune system. These two systems critically coordinate the sensations of and adaptations to dietary, microbial, and damaging stimuli from the external...