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105 results
2026
Caroline G Kahane, Lise E Nigrovic, Daping Yang, Joseph A Majzoub, Mark D Kellogg, Ron L Kaplan, Andrea T Cruz, Isaac M Chiu, and Todd W Lyons. 2026. “Calcitonin Gene-Related Peptide for Identifying Pediatric Bacterial Musculoskeletal Infections: A Prospective, Multicenter Study”. Pediatric Emergency Care. doi:https://doi.org/10.1097/pec.0000000000003520
Caroline G Kahane, Lise E Nigrovic, Daping Yang, Joseph A Majzoub, Mark D Kellogg, Ron L Kaplan, Andrea T Cruz, Isaac M Chiu, and Todd W Lyons. 2026. “Calcitonin Gene-Related Peptide for Identifying Pediatric Bacterial Musculoskeletal Infections: A Prospective, Multicenter Study”. Pediatric Emergency Care. doi:https://doi.org/10.1097/pec.0000000000003520
Objectives: Bacterial musculoskeletal infections (MSKIs) can be challenging to diagnose. We compared the accuracy of calcitonin gene-related peptide (CGRP), a neuropeptide which is transcribed from the same gene as procalcitonin, to procalcitonin for the...
Olivia Venezia, Harry Kane, Gang Du, Hannah D. Coughlan, Timothy M. Johanson, Hongshen Wang, Pathricia Tilstam, Samuel W. Kazer, Georgia Gunner, Daisy A. Hoagland, Megha G. Basavappa, Kanchana Ravichandran, Eren Ada, Ademi Zhakyp, Sandhya Kumar, Coco Duizer, Owen Searle, Chris Geo Provido, Leonel Joannas, Shilong Yang, Liam B. Healy, Qiankun Wang, Joia Capocchi, Bahawar Sharif Dhillon, Sarah Slavoff, Liang Shan, Jorge Henao-Mejia, Ruth A. Franklin, Isaac M. Chiu, Jose Ordovas-Montanes, Kate L. Jeffrey, Judy Lieberman, Rhys S. Allan, Jonathan C. Kagan, Hao Wu, and Ruaidhrí Jackson. 2026. “Functional Chimeric MRNAs Encode Proteins in Mammalian Immunity”. Nature
Olivia Venezia, Harry Kane, Gang Du, Hannah D. Coughlan, Timothy M. Johanson, Hongshen Wang, Pathricia Tilstam, Samuel W. Kazer, Georgia Gunner, Daisy A. Hoagland, Megha G. Basavappa, Kanchana Ravichandran, Eren Ada, Ademi Zhakyp, Sandhya Kumar, Coco Duizer, Owen Searle, Chris Geo Provido, Leonel Joannas, Shilong Yang, Liam B. Healy, Qiankun Wang, Joia Capocchi, Bahawar Sharif Dhillon, Sarah Slavoff, Liang Shan, Jorge Henao-Mejia, Ruth A. Franklin, Isaac M. Chiu, Jose Ordovas-Montanes, Kate L. Jeffrey, Judy Lieberman, Rhys S. Allan, Jonathan C. Kagan, Hao Wu, and Ruaidhrí Jackson. 2026. “Functional Chimeric MRNAs Encode Proteins in Mammalian Immunity”. Nature
Individual mammalian mRNAs and proteins are typically believed to originate from single genomic loci, with isoform diversity arising through cis-splicing of pre-mRNA. Whether mRNA from distant genes can undergo trans-splicing to generate functionally...
Ya-Hsuan Ho, Giacomo Bregni, Marco Stazi, Paola Peinado, Pei-Hsing Chen, Claudio Ballabio, Victoire Boulat, Shree Vadera, Yilin Guan, Zhikai Liu, Alicia Alonso de la Vega, Li Wang, Chao-Chi Ho, Henrique Veiga-Fernandes, Julian Downward, Min-Shu Hsieh, Maksym V. Kopanitsa, George Kassiotis, Christoforos Tsantoulas, Michael S. Schappe, Michael-Bogdan Margineanu, Dinis Pedro Calado, Isaac M. Chiu, Charles Swanton, Jin-Shing Chen, and Leanne Li. 2026. “Nociceptive Innervation Limits Tertiary Lymphoid Structures to Promote Lung Cancer”. Cell. doi:https://doi.org/10.1016/j.cell.2026.04.038
Ya-Hsuan Ho, Giacomo Bregni, Marco Stazi, Paola Peinado, Pei-Hsing Chen, Claudio Ballabio, Victoire Boulat, Shree Vadera, Yilin Guan, Zhikai Liu, Alicia Alonso de la Vega, Li Wang, Chao-Chi Ho, Henrique Veiga-Fernandes, Julian Downward, Min-Shu Hsieh, Maksym V. Kopanitsa, George Kassiotis, Christoforos Tsantoulas, Michael S. Schappe, Michael-Bogdan Margineanu, Dinis Pedro Calado, Isaac M. Chiu, Charles Swanton, Jin-Shing Chen, and Leanne Li. 2026. “Nociceptive Innervation Limits Tertiary Lymphoid Structures to Promote Lung Cancer”. Cell. doi:https://doi.org/10.1016/j.cell.2026.04.038
Sensory innervation regulates lung physiology and pathology, but its role in lung cancer is poorly understood. We show that lung adenocarcinoma (LUAD) progression locally amplifies nociceptive sensory innervation and activation, which drives the release...
Tiphaine Voisin, Nadine Gheziel, Céline El Samrout, Jérémy Martin, Amyaouch Bradaia, Mircea Iftinca, Manon Defaye, Aude Charron, Nasser S Abdullah, Celia Changenot, Anne-Alicia Gonzalez, Antoine Depluech, Elodie Labit, Nathalie Saint-Laurent, Larissa Staurengo-Ferrari, Ozge Erdogan, Marie Tauber, Alexia Loste, Nadine Serhan, Sara Villa-Hernandez, Isaac M Chiu, Aziz Moqrich, Christophe Altier, Lilian Basso, and Nicolas Gaudenzio. 2026. “Skin Inflammation and Itch Response Are Independently Regulated by Distinct Nociceptor Subsets”. Immunity. doi:https://doi.org/10.1016/j.immuni.2026.03.020
Tiphaine Voisin, Nadine Gheziel, Céline El Samrout, Jérémy Martin, Amyaouch Bradaia, Mircea Iftinca, Manon Defaye, Aude Charron, Nasser S Abdullah, Celia Changenot, Anne-Alicia Gonzalez, Antoine Depluech, Elodie Labit, Nathalie Saint-Laurent, Larissa Staurengo-Ferrari, Ozge Erdogan, Marie Tauber, Alexia Loste, Nadine Serhan, Sara Villa-Hernandez, Isaac M Chiu, Aziz Moqrich, Christophe Altier, Lilian Basso, and Nicolas Gaudenzio. 2026. “Skin Inflammation and Itch Response Are Independently Regulated by Distinct Nociceptor Subsets”. Immunity. doi:https://doi.org/10.1016/j.immuni.2026.03.020
Common dermatological disorders are characterized by inflammation and severe itching, which represent a significant clinical challenge. The mechanisms by which nociceptive sensory neurons (nociceptors) integrate peripheral signals to modulate inflammation...
Larissa Staurengo-Ferrari, Calvin Wong, and Isaac M. Chiu. 2026. “Neuroimmune Interferon Signals Sustain Arthritis Pain”. Nature Neuroscience. doi:https://doi.org/10.1038/s41593-026-02251-x
Larissa Staurengo-Ferrari, Calvin Wong, and Isaac M. Chiu. 2026. “Neuroimmune Interferon Signals Sustain Arthritis Pain”. Nature Neuroscience. doi:https://doi.org/10.1038/s41593-026-02251-x
Xin Jiang, Laure Schaeffer, Divya Patni, Tommaso Russo, Chao-Zong Lee, Corey Aguilar, Christine Marques, Karen Jansen-West, Marian Hruska-Plochan, Ananya Ray-Soni, Su Min Lim, Aaron Held, Mei Yue, Paula Castellanos Otero, Sandeep Aryal, Hortense D A M Beaussant, Himanish Basu, Hiro Takakuwa, Lillian M Daughrity, Nandini Ramesh, Paulo Da Costa, Ana Rita A A Quadros, Matthew Nolan, Charles Jourdan F Reyes, Hayden Wheeler, Laura C Moran, Grant Griesman, Benjamin Wymann, Bianca A Trombetta, Emma Sofia Lopez-De-Silanes, Michael Canori, Gopinath Krishnan, Yasmim Vieira Souza Da Silva, Gilbert Eriani, Mark W Albers, Steven E Arnold, Yuyu Song, Ankur Jain, Isaac M Chiu, Yong-Jie Zhang, Fen-Biao Gao, Brian J Wainger, Magdalini Polymenidou, Leonard Petrucelli, Franck Martin, and Clotilde Lagier-Tourenne. 2026. “Blocking RAN Translation Without Altering Repeat RNAs Rescues C9ORF72-Related ALS and FTD Phenotypes”. Science. doi:10.1126/science.adv2600
Xin Jiang, Laure Schaeffer, Divya Patni, Tommaso Russo, Chao-Zong Lee, Corey Aguilar, Christine Marques, Karen Jansen-West, Marian Hruska-Plochan, Ananya Ray-Soni, Su Min Lim, Aaron Held, Mei Yue, Paula Castellanos Otero, Sandeep Aryal, Hortense D A M Beaussant, Himanish Basu, Hiro Takakuwa, Lillian M Daughrity, Nandini Ramesh, Paulo Da Costa, Ana Rita A A Quadros, Matthew Nolan, Charles Jourdan F Reyes, Hayden Wheeler, Laura C Moran, Grant Griesman, Benjamin Wymann, Bianca A Trombetta, Emma Sofia Lopez-De-Silanes, Michael Canori, Gopinath Krishnan, Yasmim Vieira Souza Da Silva, Gilbert Eriani, Mark W Albers, Steven E Arnold, Yuyu Song, Ankur Jain, Isaac M Chiu, Yong-Jie Zhang, Fen-Biao Gao, Brian J Wainger, Magdalini Polymenidou, Leonard Petrucelli, Franck Martin, and Clotilde Lagier-Tourenne. 2026. “Blocking RAN Translation Without Altering Repeat RNAs Rescues C9ORF72-Related ALS and FTD Phenotypes”. Science. doi:10.1126/science.adv2600
GGGGCC (G4C2) repeat expansion in C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Toxicity is thought to result from the accumulation of either repeat RNAs and/or dipeptide repeat proteins...
2025
Duygu Payzin-Dogru, Tim Froitzheim, Steven J Blair, Siddhartha G Jena, Hani Singer, Julia C Paoli, Ryan T Kim, Emil Kriukov, Sarah E Wilson, Renzhi Hou, Aaron M Savage, Victor Cat, Louis Cammarata V, S Y Celeste Wu, Vivien Bothe, Burcu Erdogan, Shifa Hossain, Noah Lopez, Julia Losner, Juan Velazquez Matos, Sangwon Min, Sebastian Böhm, Anthony E Striker, Kelly E Dooling, Adam H Freedman, Bobby Groves, Benjamin Tajer, Glory Kalu, Eric Wynn, Alan Y L Wong, Nadia Fröbisch, Petr Baranov, Maksim Plikus V, Jason D Buenrostro, Brian J Haas, Isaac M Chiu, Timothy B Sackton, and Jessica L Whited. 2025. “Adrenergic Signaling Coordinates Distant and Local Responses to Amputation in Axolotl”. Cell. doi:https://doi.org/10.1016/j.cell.2025.09.025
Duygu Payzin-Dogru, Tim Froitzheim, Steven J Blair, Siddhartha G Jena, Hani Singer, Julia C Paoli, Ryan T Kim, Emil Kriukov, Sarah E Wilson, Renzhi Hou, Aaron M Savage, Victor Cat, Louis Cammarata V, S Y Celeste Wu, Vivien Bothe, Burcu Erdogan, Shifa Hossain, Noah Lopez, Julia Losner, Juan Velazquez Matos, Sangwon Min, Sebastian Böhm, Anthony E Striker, Kelly E Dooling, Adam H Freedman, Bobby Groves, Benjamin Tajer, Glory Kalu, Eric Wynn, Alan Y L Wong, Nadia Fröbisch, Petr Baranov, Maksim Plikus V, Jason D Buenrostro, Brian J Haas, Isaac M Chiu, Timothy B Sackton, and Jessica L Whited. 2025. “Adrenergic Signaling Coordinates Distant and Local Responses to Amputation in Axolotl”. Cell. doi:https://doi.org/10.1016/j.cell.2025.09.025
Many species regenerate lost body parts following amputation. Most limb regeneration research has focused on the immediate injury site. Meanwhile, body-wide injury responses remain largely unexplored but may be critical for regeneration. Here, we...
Deepika Sharma, Ankit Malik, Veronica Locher, Shaina McGrath, Sarah Zabala, Hardik Grover, Cezary Ciszewski, Li Chen, Daping Yang, Isaac M Chiu, and Bana Jabri. 2025. “A Myeloid Tet2-IL-1β Axis Modulates Intestinal Inflammation by Restricting Catecholaminergic Stimulation of Enterochromaffin Cell Differentiation”. Immunity. doi:https://doi.org/10.1016/j.immuni.2025.10.012
Deepika Sharma, Ankit Malik, Veronica Locher, Shaina McGrath, Sarah Zabala, Hardik Grover, Cezary Ciszewski, Li Chen, Daping Yang, Isaac M Chiu, and Bana Jabri. 2025. “A Myeloid Tet2-IL-1β Axis Modulates Intestinal Inflammation by Restricting Catecholaminergic Stimulation of Enterochromaffin Cell Differentiation”. Immunity. doi:https://doi.org/10.1016/j.immuni.2025.10.012
Deciphering multicellular interactions is essential to understanding immune-mediated diseases. Myeloid cells can coordinate inflammatory responses and are central to immune crosstalk with neuronal, epithelial, and stromal cells. Here, we show that myeloid...
Pavitha Parathan, Kelly Tran, Liam Neil, Tao Tan, Annalisa L E Carli, Yang Liao, Dmitri Mouradov, Jessica Da Gama Duarte, Anne Huber, Bhupinder Pal, Peter Gibbs, Oliver M Sieber, Isaac M Chiu, Conor J Kearney, Wei Shi, John M Mariadason, David S Williams, Michael Buchert, and Lisa A Mielke. 2025. “Sensory Neuropeptide CGRP and Its Co-Receptor RAMP1 Drive Tumour Cell Growth in Gastrointestinal Cancers”. BMJ Oncology. doi:10.1136/bmjonc-2025-000842
Pavitha Parathan, Kelly Tran, Liam Neil, Tao Tan, Annalisa L E Carli, Yang Liao, Dmitri Mouradov, Jessica Da Gama Duarte, Anne Huber, Bhupinder Pal, Peter Gibbs, Oliver M Sieber, Isaac M Chiu, Conor J Kearney, Wei Shi, John M Mariadason, David S Williams, Michael Buchert, and Lisa A Mielke. 2025. “Sensory Neuropeptide CGRP and Its Co-Receptor RAMP1 Drive Tumour Cell Growth in Gastrointestinal Cancers”. BMJ Oncology. doi:10.1136/bmjonc-2025-000842
Objective: The gastrointestinal (GI) tract is densely innervated, forming a critical network that secretes neuropeptides essential for gut function. Tumour cells are highly adaptive and exploit their microenvironment, including nerves, to support and...
Nicole Almanzar, Daping Yang, Jingya Xia, Swalpa Udit, Prabhu Joshi, Sandeep Adhikari, Daisy A Hoagland, Stephen T Yeung, Camille Khairallah, Tomas Huerta, Antonia Wallrapp, Benjamin D Umans, Nicole Sarden, Ozge Erdogan, Nadia Baalbaki, Jiawei Hou, Anna Beekmayer-Dhillon, Juhyun Lee, Kimberly A Meerschaert, Stephen D Liberles, Ruth A Franklin, Bryan G Yipp, Kamal M Khanna, Pankaj Baral, Adam L Haber, and Isaac M Chiu. 2025. “Vagal TRPV1 Sensory Neurons Protect Against Influenza Virus Infection by Regulating Lung Myeloid Cell Dynamics.”. Science Immunology, 10, 110, Pp. eads6243. doi:10.1126/sciimmunol.ads6243
Nicole Almanzar, Daping Yang, Jingya Xia, Swalpa Udit, Prabhu Joshi, Sandeep Adhikari, Daisy A Hoagland, Stephen T Yeung, Camille Khairallah, Tomas Huerta, Antonia Wallrapp, Benjamin D Umans, Nicole Sarden, Ozge Erdogan, Nadia Baalbaki, Jiawei Hou, Anna Beekmayer-Dhillon, Juhyun Lee, Kimberly A Meerschaert, Stephen D Liberles, Ruth A Franklin, Bryan G Yipp, Kamal M Khanna, Pankaj Baral, Adam L Haber, and Isaac M Chiu. 2025. “Vagal TRPV1 Sensory Neurons Protect Against Influenza Virus Infection by Regulating Lung Myeloid Cell Dynamics.”. Science Immunology, 10, 110, Pp. eads6243. doi:10.1126/sciimmunol.ads6243
Influenza viruses are a major global cause of morbidity and mortality. Although vagal TRPV1 nociceptive sensory neurons are known to mediate defenses against harmful agents, including pathogens, their function in lung antiviral defenses remains unclear...
Georgia Gunner, Himanish Basu, Yueting Lu, Matthew Bergstresser, Liwei Sun, Dylan Neel, So Yoen Choi, and Isaac M Chiu. 2025. “Gasdermin D Is Activated But Does Not Drive Neurodegeneration in SOD1 Model of ALS: Implications for Targeting Pyroptosis.”. Neurobiology of Disease, 214, Pp. 107048. doi:10.1016/j.nbd.2025.107048
Georgia Gunner, Himanish Basu, Yueting Lu, Matthew Bergstresser, Liwei Sun, Dylan Neel, So Yoen Choi, and Isaac M Chiu. 2025. “Gasdermin D Is Activated But Does Not Drive Neurodegeneration in SOD1 Model of ALS: Implications for Targeting Pyroptosis.”. Neurobiology of Disease, 214, Pp. 107048. doi:10.1016/j.nbd.2025.107048
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive motor neuron loss, microgliosis, and neuroinflammation. While pyroptosis, an inflammatory form of programmed cell death, has been implicated in ALS, the...
Himanish Basu, Coco Holliday, and Isaac M. Chiu. 2025. “Neuronal VPS13D Loss Drives Microglial Activation”. Nature Structural & Molecular Biology
Himanish Basu, Coco Holliday, and Isaac M. Chiu. 2025. “Neuronal VPS13D Loss Drives Microglial Activation”. Nature Structural & Molecular Biology