Citation:
Ming Zhang, Elisabeth M Alicot, Isaac Chiu, Jinan Li, Nicola Verna, Thomas Vorup-Jensen, Benedikt Kessler, Motomu Shimaoka, Rodney Chan, Daniel Friend, Umar Mahmood, Ralph Weissleder, Francis D Moore, and Michael C Carroll. 2006. “Identification of the target self-antigens in reperfusion injury.” J Exp Med, 203, 1, Pp. 141-52. Copy at http://www.tinyurl.com/y2asmv92
Abstract:
Reperfusion injury (RI), a potential life-threatening disorder, represents an acute inflammatory response after periods of ischemia resulting from myocardial infarction, stroke, surgery, or trauma. The recent identification of a monoclonal natural IgM that initiates RI led to the identification of nonmuscle myosin heavy chain type II A and C as the self-targets in two different tissues. These results identify a novel pathway in which the innate response to a highly conserved self-antigen expressed as a result of hypoxic stress results in tissue destruction.See also: Primary Research Papers