Publications
Sort & Filters
Filters
104 results
104 results
2022
Swalpa Udit, Kimbria Blake, and Isaac Chiu. 2022. “Somatosensory and Autonomic Neuronal Regulation of the Immune Response”. Nat Rev Neurosci, 23, 3, Pp. 157-71. doi:10.1038/s41583-021-00555-4
Swalpa Udit, Kimbria Blake, and Isaac Chiu. 2022. “Somatosensory and Autonomic Neuronal Regulation of the Immune Response”. Nat Rev Neurosci, 23, 3, Pp. 157-71. doi:10.1038/s41583-021-00555-4
Bidirectional communication between the peripheral nervous system (PNS) and the immune system is a crucial part of an effective but balanced mammalian response to invading pathogens, tissue damage and inflammatory stimuli. Here, we review how...
Lars Clark, Sarah Clark, ChieYu Lin, Jianying Liu, Adrian Coscia, Katherine Nabel, Pan Yang, Dylan Neel, Hyo Lee, Vesna Brusic, Iryna Stryapunina, Kenneth Plante, Asim Ahmed, Flaminia Catteruccia, Tracy Young-Pearse, Isaac Chiu, Paula Montero Llopis, Scott Weaver, and Jonathan Abraham. 2022. “VLDLR and ApoER2 Are Receptors for Multiple Alphaviruses”. Nature, 602, 7897, Pp. 475-80. doi:10.1038/s41586-021-04326-0
Lars Clark, Sarah Clark, ChieYu Lin, Jianying Liu, Adrian Coscia, Katherine Nabel, Pan Yang, Dylan Neel, Hyo Lee, Vesna Brusic, Iryna Stryapunina, Kenneth Plante, Asim Ahmed, Flaminia Catteruccia, Tracy Young-Pearse, Isaac Chiu, Paula Montero Llopis, Scott Weaver, and Jonathan Abraham. 2022. “VLDLR and ApoER2 Are Receptors for Multiple Alphaviruses”. Nature, 602, 7897, Pp. 475-80. doi:10.1038/s41586-021-04326-0
Alphaviruses, like many other arthropod-borne viruses, infect vertebrate species and insect vectors separated by hundreds of millions of years of evolutionary history. Entry into evolutionarily divergent host cells can be accomplished by recognition of...
Nicole Yang, Jörg Isensee, Dylan Neel, Andreza Quadros, Han-Xiong Bear Zhang, Justas Lauzadis, Sai Man Liu, Stephanie Shiers, Andreea Belu, Shilpa Palan, Sandra Marlin, Jacquie Maignel, Angela Kennedy-Curran, Victoria Tong, Mahtab Moayeri, Pascal Röderer, Anja Nitzsche, Mike Lu, Bradley Pentelute, Oliver Brüstle, Vineeta Tripathi, Keith Foster, Theodore Price, John Collier, Stephen Leppla, Michelino Puopolo, Bruce Bean, Thiago Cunha, Tim Hucho, and Isaac Chiu. 2022. “Anthrax Toxins Regulate Pain Signaling and Can Deliver Molecular Cargoes into ANTXR2+ DRG Sensory Neurons”. Nat Neurosci, 25, 2, Pp. 168-79. doi:10.1038/s41593-021-00973-8
Nicole Yang, Jörg Isensee, Dylan Neel, Andreza Quadros, Han-Xiong Bear Zhang, Justas Lauzadis, Sai Man Liu, Stephanie Shiers, Andreea Belu, Shilpa Palan, Sandra Marlin, Jacquie Maignel, Angela Kennedy-Curran, Victoria Tong, Mahtab Moayeri, Pascal Röderer, Anja Nitzsche, Mike Lu, Bradley Pentelute, Oliver Brüstle, Vineeta Tripathi, Keith Foster, Theodore Price, John Collier, Stephen Leppla, Michelino Puopolo, Bruce Bean, Thiago Cunha, Tim Hucho, and Isaac Chiu. 2022. “Anthrax Toxins Regulate Pain Signaling and Can Deliver Molecular Cargoes into ANTXR2+ DRG Sensory Neurons”. Nat Neurosci, 25, 2, Pp. 168-79. doi:10.1038/s41593-021-00973-8
Bacterial products can act on neurons to alter signaling and function. In the present study, we found that dorsal root ganglion (DRG) sensory neurons are enriched for ANTXR2, the high-affinity receptor for anthrax toxins. Anthrax toxins are composed of...
2021
Liwen Deng and Isaac Chiu. 2021. “Microbes and Pain”. PLoS Pathog, 17, 4, Pp. e1009398. doi:10.1371/journal.ppat.1009398
Liwen Deng and Isaac Chiu. 2021. “Microbes and Pain”. PLoS Pathog, 17, 4, Pp. e1009398. doi:10.1371/journal.ppat.1009398
Yiqing Yan, Deepshika Ramanan, Milena Rozenberg, Kelly McGovern, Daniella Rastelli, Brinda Vijaykumar, Omar Yaghi, Tiphaine Voisin, Munir Mosaheb, Isaac Chiu, Shalev Itzkovitz, Meenakshi Rao, Diane Mathis, and Christophe Benoist. 2021. “Interleukin-6 Produced by Enteric Neurons Regulates the Number and Phenotype of Microbe-Responsive Regulatory T Cells in the Gut”. Immunity, 54, 3, Pp. 499-513.e5. doi:10.1016/j.immuni.2021.02.002
Yiqing Yan, Deepshika Ramanan, Milena Rozenberg, Kelly McGovern, Daniella Rastelli, Brinda Vijaykumar, Omar Yaghi, Tiphaine Voisin, Munir Mosaheb, Isaac Chiu, Shalev Itzkovitz, Meenakshi Rao, Diane Mathis, and Christophe Benoist. 2021. “Interleukin-6 Produced by Enteric Neurons Regulates the Number and Phenotype of Microbe-Responsive Regulatory T Cells in the Gut”. Immunity, 54, 3, Pp. 499-513.e5. doi:10.1016/j.immuni.2021.02.002
The immune and enteric nervous (ENS) systems monitor the frontier with commensal and pathogenic microbes in the colon. We investigated whether FoxP3 regulatory T (Treg) cells functionally interact with the ENS. Indeed, microbe-responsive RORγ and Helios...
Tiphaine Voisin, Caroline Perner, Marie-Angele Messou, Stephanie Shiers, Saltanat Ualiyeva, Yoshihide Kanaoka, Theodore Price, Caroline Sokol, Lora Bankova, Frank Austen, and Isaac Chiu. 2021. “The CysLT2R Receptor Mediates Leukotriene C4-Driven Acute and Chronic Itch”. Proc Natl Acad Sci U S A, 118, 13. doi:10.1073/pnas.2022087118
Tiphaine Voisin, Caroline Perner, Marie-Angele Messou, Stephanie Shiers, Saltanat Ualiyeva, Yoshihide Kanaoka, Theodore Price, Caroline Sokol, Lora Bankova, Frank Austen, and Isaac Chiu. 2021. “The CysLT2R Receptor Mediates Leukotriene C4-Driven Acute and Chronic Itch”. Proc Natl Acad Sci U S A, 118, 13. doi:10.1073/pnas.2022087118
Acute and chronic itch are burdensome manifestations of skin pathologies including allergic skin diseases and atopic dermatitis, but the underlying molecular mechanisms are not well understood. Cysteinyl leukotrienes (CysLTs), comprising LTC, LTD, and LTE...
Liliana Sanmarco, Michael Wheeler, Cristina Gutiérrez-Vázquez, Carolina Manganeli Polonio, Mathias Linnerbauer, Felipe Pinho-Ribeiro, Zhaorong Li, Federico Giovannoni, Katelyn Batterman, Giulia Scalisi, Stephanie Zandee, Evelyn Heck, Moneera Alsuwailm, Douglas Rosene, Burkhard Becher, Isaac Chiu, Alexandre Prat, and Francisco Quintana. 2021. “Gut-Licensed IFNγ+ NK Cells Drive LAMP1+ TRAIL+ Anti-Inflammatory Astrocytes”. Nature, 590, 7846, Pp. 473-79. doi:10.1038/s41586-020-03116-4
Liliana Sanmarco, Michael Wheeler, Cristina Gutiérrez-Vázquez, Carolina Manganeli Polonio, Mathias Linnerbauer, Felipe Pinho-Ribeiro, Zhaorong Li, Federico Giovannoni, Katelyn Batterman, Giulia Scalisi, Stephanie Zandee, Evelyn Heck, Moneera Alsuwailm, Douglas Rosene, Burkhard Becher, Isaac Chiu, Alexandre Prat, and Francisco Quintana. 2021. “Gut-Licensed IFNγ+ NK Cells Drive LAMP1+ TRAIL+ Anti-Inflammatory Astrocytes”. Nature, 590, 7846, Pp. 473-79. doi:10.1038/s41586-020-03116-4
Astrocytes are glial cells that are abundant in the central nervous system (CNS) and that have important homeostatic and disease-promoting functions. However, little is known about the homeostatic anti-inflammatory activities of astrocytes and their...
Amanda Jacobson, Daping Yang, Madeleine Vella, and Isaac Chiu. 2021. “The Intestinal Neuro-Immune Axis: Crosstalk Between Neurons, Immune Cells, and Microbes”. Mucosal Immunol. doi:10.1038/s41385-020-00368-1
Amanda Jacobson, Daping Yang, Madeleine Vella, and Isaac Chiu. 2021. “The Intestinal Neuro-Immune Axis: Crosstalk Between Neurons, Immune Cells, and Microbes”. Mucosal Immunol. doi:10.1038/s41385-020-00368-1
The gastrointestinal tract is densely innervated by a complex network of neurons that coordinate critical physiological functions. Here, we summarize recent studies investigating the crosstalk between gut-innervating neurons, resident immune cells, and...
Nicole Yang, Dylan Neel, Liwen Deng, Michelle Heyang, Angela Kennedy-Curran, Victoria Tong, Jin Mo Park, and Isaac Chiu. 2021. “Nociceptive Sensory Neurons Mediate Inflammation Induced by Edema Toxin”. Front Immunol, 12, Pp. 642373. doi:10.3389/fimmu.2021.642373
Nicole Yang, Dylan Neel, Liwen Deng, Michelle Heyang, Angela Kennedy-Curran, Victoria Tong, Jin Mo Park, and Isaac Chiu. 2021. “Nociceptive Sensory Neurons Mediate Inflammation Induced by Edema Toxin”. Front Immunol, 12, Pp. 642373. doi:10.3389/fimmu.2021.642373
Bacterial products are able to act on nociceptive neurons during pathogenic infection. Neurogenic inflammation is an active part of pain signaling and has recently been shown to impact host-pathogen defense. Bacillus anthracis Edema Toxin (ET) produces...
2020
Nicole Lai, Melissa Musser, Felipe Pinho-Ribeiro, Pankaj Baral, Amanda Jacobson, Pingchuan Ma, David Potts, Zuojia Chen, Donggi Paik, Salima Soualhi, Yiqing Yan, Aditya Misra, Kaitlin Goldstein, Valentina Lagomarsino, Anja Nordstrom, Kisha Sivanathan, Antonia Wallrapp, Vijay Kuchroo, Roni Nowarski, Michael Starnbach, Hailian Shi, Neeraj Surana, Dingding An, Chuan Wu, Jun Huh, Meenakshi Rao, and Isaac Chiu. 2020. “Gut-Innervating Nociceptor Neurons Regulate Peyer’s Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense”. Cell, 180, 1, Pp. 33-49.e22. doi:10.1016/j.cell.2019.11.014
Nicole Lai, Melissa Musser, Felipe Pinho-Ribeiro, Pankaj Baral, Amanda Jacobson, Pingchuan Ma, David Potts, Zuojia Chen, Donggi Paik, Salima Soualhi, Yiqing Yan, Aditya Misra, Kaitlin Goldstein, Valentina Lagomarsino, Anja Nordstrom, Kisha Sivanathan, Antonia Wallrapp, Vijay Kuchroo, Roni Nowarski, Michael Starnbach, Hailian Shi, Neeraj Surana, Dingding An, Chuan Wu, Jun Huh, Meenakshi Rao, and Isaac Chiu. 2020. “Gut-Innervating Nociceptor Neurons Regulate Peyer’s Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense”. Cell, 180, 1, Pp. 33-49.e22. doi:10.1016/j.cell.2019.11.014
Gut-innervating nociceptor sensory neurons respond to noxious stimuli by initiating protective responses including pain and inflammation; however, their role in enteric infections is unclear. Here, we find that nociceptor neurons critically mediate...
Isaac Chiu and Asya Rolls. 2020. “Editorial Overview: Brain, Gut and Immune System Interactions”. Curr Opin Neurobiol, 62, Pp. iii-v
Isaac Chiu and Asya Rolls. 2020. “Editorial Overview: Brain, Gut and Immune System Interactions”. Curr Opin Neurobiol, 62, Pp. iii-v
Isabelle A. M. Thiel, Wouter J. Jonge, Isaac Chiu, and Rene M. Wijngaard. 2020. “Microbiota-Neuroimmune Cross Talk in Stress-Induced Visceral Hypersensitivity of the Bowel”. Am J Physiol Gastrointest Liver Physiol, 318, 6, Pp. G1034-G1041
Isabelle A. M. Thiel, Wouter J. Jonge, Isaac Chiu, and Rene M. Wijngaard. 2020. “Microbiota-Neuroimmune Cross Talk in Stress-Induced Visceral Hypersensitivity of the Bowel”. Am J Physiol Gastrointest Liver Physiol, 318, 6, Pp. G1034-G1041
Visceral hypersensitivity of the lower gastrointestinal tract, defined as an increased response to colorectal disten- sion, frequently prompts episodes of debilitating abdominal pain in irritable bowel syndrome (IBS). Although the pathophysiology of IBS...