Enteric glial cells mediate gut immunity and repair
Publication information:
Antonia Wallrapp, Daping Yang, and Isaac Chiu. 2022. “Enteric Glial Cells Mediate Gut Immunity and Repair”. Trends Neurosci, 45, 4, Pp. 251-53. doi:10.1016/j.tins.2021.12.001
Abstract
In the gut, coordinated cell interactions regulate tissue repair and immunity. How enteric glial cells (EGCs) mediate these processes remained elusive. In a recent paper, Progatzky et al. demonstrate that EGCs interact with immune and mesothelial cells under homeostasis and helminth infection, revealing an indispensable role of an interferon-γ (IFNγ)-EGC-CXCL10 axis in tissue repair.