@article {1480800,
	title = {Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation},
	journal = {Neuron},
	volume = {87},
	number = {2},
	year = {2015},
	month = {2015 Jul 15},
	pages = {341-54},
	abstract = {Lung nociceptors initiate cough and bronchoconstriction. To elucidate if these fibers also contribute to allergic airway inflammation, we stimulated lung nociceptors with capsaicin and observed increased neuropeptide release and immune cell infiltration. In contrast, ablating Nav1.8(+) sensory neurons or silencing them with QX-314, a charged sodium channel inhibitor that enters via large-pore ion channels to specifically block nociceptors, substantially reduced ovalbumin- or house-dust-mite-induced airway inflammation and bronchial hyperresponsiveness. We also discovered that IL-5, a cytokine produced by activated immune cells, acts directly on nociceptors to induce the release of vasoactive intestinal peptide (VIP). VIP then stimulates CD4(+) and resident innate lymphoid type 2 cells, creating an inflammatory signaling loop that promotes allergic inflammation. Our results indicate that nociceptors amplify pathological adaptive immune responses and that silencing these neurons with QX-314 interrupts this neuro-immune interplay, revealing a potential new therapeutic strategy for asthma.},
	keywords = {Airway Remodeling, Anesthetics, Local, Animals, Animals, Newborn, Capsaicin, Cytokines, Disease Models, Animal, Freund{\textquoteright}s Adjuvant, Green Fluorescent Proteins, Interleukin-5, Lidocaine, Mice, Nociceptors, Ovalbumin, Respiratory Hypersensitivity, Time Factors, Vasoactive Intestinal Peptide},
	issn = {1097-4199},
	doi = {10.1016/j.neuron.2015.06.007},
	author = {Talbot, S{\'e}bastien and Abdulnour, Raja-Elie E and Burkett, Patrick R and Lee, Seungkyu and Cronin, Shane J F and Pascal, Maud A and Laedermann, Cedric and Foster, Simmie L and Tran, Johnathan V and Lai, Nicole and Chiu, Isaac M and Ghasemlou, Nader and DiBiase, Matthew and Roberson, David and Von Hehn, Christian and Agac, Busranour and Haworth, Oliver and Seki, Hiroyuki and Penninger, Josef M and Kuchroo, Vijay K and Bean, Bruce P and Levy, Bruce D and Woolf, Clifford J}
}
