@article {1480778,
	title = {Gut-Innervating Nociceptor Neurons Regulate Peyer{\textquoteright}s Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense},
	journal = {Cell},
	volume = {180},
	number = {1},
	year = {2020},
	note = {
	
		News \&amp; Views. Romana R. Gerner and Manuela Raffatellu. Gut pain sensors help to combat infection.\&nbsp;Nature. 2020 Apr;580(7805):594-595.
	
	
		Preview by Cameron Flayer and Caroline Sokol. Nerves of Steel: How the gut nervous system promotes a strong barrier. Cell. Jan 9;180(1)15-17. 
	
	
		Comment by Katherine Whalley. Defending the Gut. Nature Reviews Neuroscience. 2020 Feb;21(2):59. 
	
	
		Comment by Iain Dickson. A role of nociceptor neurons in gut defence. Nature Reviews Gastroenterol Hepatol. 2020 Feb;17(2)65.
	
	
		Comment by Stuart Brierley. Nociceptors: sentinels promoting host defence. Cell Research. 2020 Apr;30(4):279-280.
	
	
		Featured in the Harvard Gazette and Harvard Medical School News.
	

},
	month = {2020 Jan 09},
	pages = {33-49.e22},
	abstract = {
	\&nbsp;



	Gut-innervating nociceptor sensory neurons respond to noxious stimuli by initiating protective responses including pain and inflammation; however, their role in enteric infections is unclear. Here, we find that nociceptor neurons critically mediate host defense against the bacterial pathogen Salmonella enterica serovar Typhimurium (STm). Dorsal root ganglia nociceptors protect against STm colonization, invasion, and dissemination from the gut. Nociceptors regulate the density of microfold (M) cells in ileum Peyer{\textquoteright}s patch (PP) follicle-associated epithelia (FAE) to limit entry points for STm invasion. Downstream of M cells, nociceptors maintain levels of segmentous filamentous bacteria (SFB), a gut microbe residing on ileum villi and PP FAE that mediates resistance to STm infection. TRPV1+ nociceptors directly respond to STm by releasing calcitonin gene-related peptide (CGRP), a neuropeptide that modulates M cells and SFB levels to protect against Salmonella infection. These findings reveal a major role for nociceptor neurons in sensing and defending against enteric pathogens.

},
	issn = {1097-4172},
	doi = {10.1016/j.cell.2019.11.014},
	author = {Lai, Nicole Y and Musser, Melissa A and Pinho-Ribeiro, Felipe A and Baral, Pankaj and Jacobson, Amanda and Ma, Pingchuan and Potts, David E and Chen, Zuojia and Paik, Donggi and Soualhi, Salima and Yan, Yiqing and Misra, Aditya and Goldstein, Kaitlin and Lagomarsino, Valentina N and Nordstrom, Anja and Sivanathan, Kisha N and Wallrapp, Antonia and Kuchroo, Vijay K and Nowarski, Roni and Starnbach, Michael N and Shi, Hailian and Surana, Neeraj K and An, Dingding and Wu, Chuan and Huh, Jun R and Rao, Meenakshi and Chiu, Isaac M}
}
