# Chiu Lab Welcome to the Chiu Lab ![chiu](/sites/g/files/omnuum8911/files/styles/hwp_21_9__1920x825/public/2025-07/HMS%20Dept%20of%20Immunology-11%5B82%5D_1.JPG?itok=fvOu984f) ![chiulab](/sites/g/files/omnuum8911/files/styles/hwp_1_1__360x360_scale/public/chiu/files/logo_by_na4.png?itok=GmV9U3WG) The Chiu lab is focused on the neuroimmune mechanisms underlying pain, host defense and neurodegeneration. Our lab is located in the vibrant scientific community at Harvard Medical School in the Department of Immunology. Major goals include uncovering mechanisms underlying: 1) How bacterial pathogens interact with the sensory nervous system to produce pain and itch. 2) How perierpheral neurons crosstalk with immune cells in barrier tissues to regulate immunity (gut-brain-axis, meninges, skin and lung immunity). 3) Role of Gasdermins and inanate immunity in CNS neurodegeneration. ## News Stories [### Naija's presentation at Synaptogenesis Symposium ](/news/2025/11/naijas-presentation-synaptogenesis-symposium) November 10, 2025 Naija Barakat, Chiu lab research assistant and PiNBAC trainee gave a fantastic talk at the 4th annual Synaptogenesis symposium! Thanks to Harvard Brain Science Initiative and HMS Department of Neurobiology for hosting! ![NB](/sites/g/files/omnuum8911/files/styles/hwp_16_9__480x270/public/2025-11/IMG_4636_0.jpg?h=bfe0be3b&itok=e3RPve6t) [### Congratulations to Georgia for her paper! ](/news/2025/09/congratulations-georgia-her-paper) September 24, 2025 Congratulations to Georgia on her new paper “Gasdermin D is activated but does not drive neurodegeneration in SOD1 model of ALS: Implications for targeting pyroptosis”, published in Neurobiology of Disease! The Chiu lab got together over lunch to... ![gg](/sites/g/files/omnuum8911/files/styles/hwp_16_9__480x270/public/2025-09/Screenshot%202025-09-24%20at%2011.39.59%E2%80%AFAM.png?h=6f0caf82&itok=uE2GlNAL) [### Jessie's poster presentation at the Harvard immunology summer program ](/news/2025/08/jessies-poster-presentation-harvard-immunology-summer-program) August 07, 2025 Jessie, who is an undergraduate in the Chiu Lab, presented her poster at the Harvard Immunology Summer Program on August 7th, 2025. We are proud of her hard work and are excited to see her build on this achievement and continue making meaningful... ![jessie](/sites/g/files/omnuum8911/files/styles/hwp_16_9__480x270/public/2025-08/image2.jpeg?itok=Vsce_Gj1) [### Congratulations to Nicole for her Science Immunology paper! ](/news/2025/07/congratulations-nicole-her-science-immunology-paper) July 30, 2025 Congratulations to Nicole on her new paper on how vagal sensory neurons regulate influenza virus infections, published in Science Immunology! Together, the lab celebrated her great achievement and efforts in driving this project toward publication by... ![na](/sites/g/files/omnuum8911/files/styles/hwp_16_9__480x270/public/2025-07/Screenshot%202025-07-30%20at%2011.12.39%E2%80%AFAM.png?h=efd7ad44&itok=_3jBGW0D) [### Naija's poster presentation at NESS ](/news/2025/03/naijas-poster-presentation-ness) March 31, 2025 Naija Barakat, our talented PiNBAC trainee presented a poster at New England Science Symposium on March 30th, 2025. It was great seeing all of her hard work in the Chiu lab and we look forward to seeing her continued growth and future contributions to the... ![IMG_1227.png](/sites/g/files/omnuum8911/files/styles/hwp_16_9__480x270/public/2025-03/IMG_1227_1.png?itok=CY5ntxCc) [### Check out Becca's feature in Emmanuel College's "The Pulse" ](/news/check-out-beccas-feature-emmanuel-colleges-pulse) February 05, 2025 An undergraduate student from our lab, Rebecca Markie is featured in an article by Emmanuel College's T he Pulse. Click on the link below to learn more about Becca's work in the Chiu lab and her achievements on campus! ... ![becca](/sites/g/files/omnuum8911/files/styles/hwp_16_9__480x270/public/475452141_18488212771001832_6334510021005393504_n.jpg?itok=tyCcuHF0) [### Celebration for Isaac's recent tenure promotion ](/news/celebration-isaacs-recent-tenure-promotion-0) February 03, 2025 We would like to thank the immunology department for organizing a wonderful celebration. We got to see so many impactful people from Isaac's career. Thank you to everyone who came, and congratulations, Professor Chiu! ![chiu](/sites/g/files/omnuum8911/files/styles/hwp_16_9__480x270/public/2025-04/isaac-chui-0015_01.jpg?h=78f97116&itok=rO7rnXnd) [### Congratulations Isaac on Tenure! ](/news/congratulations-isaac-tenure) October 17, 2024 Congrats to Dr. Chiu on his promotion to Professor of Immunology! Here's to many more years of productive and impactful research! ![img_0235.jpg](/sites/g/files/omnuum8911/files/styles/hwp_16_9__480x270/public/img_0235.jpg?itok=kokq3HdB) [### Kim and yangyang's paper published today in Science! ](/news/kim-and-yangyangs-paper-published-today-science) August 02, 2024 We are super excited that Kim Meerschaert and Yangyang Zhu's paper was published today in Science magazine: . This was a fruitful collaboration between our lab and Dr. Christophe Benoist's lab... ![science.adk1679-fa.jpg](/sites/g/files/omnuum8911/files/styles/hwp_16_9__480x270/public/science.adk1679-fa.jpg?itok=I5UKmilt) [ More arrow\_circle\_right ](/news) ## Our Community Our laboratory is part of a vibrant scientific community at Harvard Medical School within the Department of Immunology. Our lab is located on the 8th floor of the 4 Blackfan Circle Building. We actively participate in several graduate student programs, including the PhD programs in BBS, Neuroscience, and Immunology. We are also members of the Harvard Digestive Disease Center and Harvard Stem Cell Institute. [### Harvard Medical School Department of Immunology ](https://immunology.hms.harvard.edu/) [### PhD Program in Immunology ](https://www.hms.harvard.edu/dms/immunology/) [### PhD Program in Biological and Biomedical Sciences (BBS) ](https://www.hms.harvard.edu/dms/bbs/) [### PhD Program in Neuroscience (PiN) ](https://www.hms.harvard.edu/dms/neuroscience/) [### Harvard Brain Sciences Inititative ](https://https//brain.harvard.edu/) ## Recent Publications Download 8 citations download- [BibTeX](/bibcite/export?pager_style=no_pager&number_of_items=8&sort_field=bibcite_year--desc&taxonomy_filters=&&additional_filters%5Btype%5D%5B0%5D%5Bvalue%5D%5B0%5D=journal_article&additional_filters%5Btype%5D%5B0%5D%5Bvalue%5D%5B1%5D=manuscript&additional_filters%5Btype%5D%5B0%5D%5Boperator%5D=IN&format=bibtex) - [EndNote X3 XML](/bibcite/export?pager_style=no_pager&number_of_items=8&sort_field=bibcite_year--desc&taxonomy_filters=&&additional_filters%5Btype%5D%5B0%5D%5Bvalue%5D%5B0%5D=journal_article&additional_filters%5Btype%5D%5B0%5D%5Bvalue%5D%5B1%5D=manuscript&additional_filters%5Btype%5D%5B0%5D%5Boperator%5D=IN&format=endnote8) - [EndNote 7 XML](/bibcite/export?pager_style=no_pager&number_of_items=8&sort_field=bibcite_year--desc&taxonomy_filters=&&additional_filters%5Btype%5D%5B0%5D%5Bvalue%5D%5B0%5D=journal_article&additional_filters%5Btype%5D%5B0%5D%5Bvalue%5D%5B1%5D=manuscript&additional_filters%5Btype%5D%5B0%5D%5Boperator%5D=IN&format=endnote7) - [Endnote tagged](/bibcite/export?pager_style=no_pager&number_of_items=8&sort_field=bibcite_year--desc&taxonomy_filters=&&additional_filters%5Btype%5D%5B0%5D%5Bvalue%5D%5B0%5D=journal_article&additional_filters%5Btype%5D%5B0%5D%5Bvalue%5D%5B1%5D=manuscript&additional_filters%5Btype%5D%5B0%5D%5Boperator%5D=IN&format=tagged) - [Marc](/bibcite/export?pager_style=no_pager&number_of_items=8&sort_field=bibcite_year--desc&taxonomy_filters=&&additional_filters%5Btype%5D%5B0%5D%5Bvalue%5D%5B0%5D=journal_article&additional_filters%5Btype%5D%5B0%5D%5Bvalue%5D%5B1%5D=manuscript&additional_filters%5Btype%5D%5B0%5D%5Boperator%5D=IN&format=marc) - [PubMedId](/bibcite/export?pager_style=no_pager&number_of_items=8&sort_field=bibcite_year--desc&taxonomy_filters=&&additional_filters%5Btype%5D%5B0%5D%5Bvalue%5D%5B0%5D=journal_article&additional_filters%5Btype%5D%5B0%5D%5Bvalue%5D%5B1%5D=manuscript&additional_filters%5Btype%5D%5B0%5D%5Boperator%5D=IN&format=pubmed_id) - [RIS](/bibcite/export?pager_style=no_pager&number_of_items=8&sort_field=bibcite_year--desc&taxonomy_filters=&&additional_filters%5Btype%5D%5B0%5D%5Bvalue%5D%5B0%5D=journal_article&additional_filters%5Btype%5D%5B0%5D%5Bvalue%5D%5B1%5D=manuscript&additional_filters%5Btype%5D%5B0%5D%5Boperator%5D=IN&format=ris) ### 2026 Caroline G Kahane, Lise E Nigrovic, Daping Yang, Joseph A Majzoub, Mark D Kellogg, Ron L Kaplan, Andrea T Cruz, Isaac M Chiu, and Todd W Lyons. 2026. “[Calcitonin Gene-Related Peptide for Identifying Pediatric Bacterial Musculoskeletal Infections: A Prospective, Multicenter Study](https://journals.lww.com/pec-online/pages/articleviewer.aspx?year=2026&issue=03000&article=00002&type=Fulltext)”. Pediatric Emergency Care. doi:https://doi.org/10.1097/pec.0000000000003520 Caroline G Kahane, Lise E Nigrovic, Daping Yang, Joseph A Majzoub, Mark D Kellogg, Ron L Kaplan, Andrea T Cruz, Isaac M Chiu, and Todd W Lyons. 2026. “[Calcitonin Gene-Related Peptide for Identifying Pediatric Bacterial Musculoskeletal Infections: A Prospective, Multicenter Study](https://journals.lww.com/pec-online/pages/articleviewer.aspx?year=2026&issue=03000&article=00002&type=Fulltext)”. Pediatric Emergency Care. doi:https://doi.org/10.1097/pec.0000000000003520 - add\_circle do\_not\_disturb\_on Abstract - [ picture\_as\_pdfPediatricEmergencyCare.pd...](/sites/g/files/omnuum8911/files/2026-07/calcitonin_gene_related_peptide_for_identifying.2.pdf) **Objectives:** Bacterial musculoskeletal infections (MSKIs) can be challenging to diagnose. We compared the accuracy of calcitonin gene-related peptide (CGRP), a neuropeptide which is transcribed from the same gene as procalcitonin, to procalcitonin for the... - [ picture\_as\_pdfPediatricEmergencyCare.pd...](/sites/g/files/omnuum8911/files/2026-07/calcitonin_gene_related_peptide_for_identifying.2.pdf) Tiphaine Voisin, Nadine Gheziel, Céline El Samrout, Jérémy Martin, Amyaouch Bradaia, Mircea Iftinca, Manon Defaye, Aude Charron, Nasser S Abdullah, Celia Changenot, Anne-Alicia Gonzalez, Antoine Depluech, Elodie Labit, Nathalie Saint-Laurent, Larissa Staurengo-Ferrari, Ozge Erdogan, Marie Tauber, Alexia Loste, Nadine Serhan, Sara Villa-Hernandez, Isaac M Chiu, Aziz Moqrich, Christophe Altier, Lilian Basso, and Nicolas Gaudenzio. 2026. “[Skin Inflammation and Itch Response Are Independently Regulated by Distinct Nociceptor Subsets](https://www.cell.com/immunity/fulltext/S1074-7613(26)00131-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761326001317%3Fshowall%3Dtrue)”. Immunity. doi:https://doi.org/10.1016/j.immuni.2026.03.020 Tiphaine Voisin, Nadine Gheziel, Céline El Samrout, Jérémy Martin, Amyaouch Bradaia, Mircea Iftinca, Manon Defaye, Aude Charron, Nasser S Abdullah, Celia Changenot, Anne-Alicia Gonzalez, Antoine Depluech, Elodie Labit, Nathalie Saint-Laurent, Larissa Staurengo-Ferrari, Ozge Erdogan, Marie Tauber, Alexia Loste, Nadine Serhan, Sara Villa-Hernandez, Isaac M Chiu, Aziz Moqrich, Christophe Altier, Lilian Basso, and Nicolas Gaudenzio. 2026. “[Skin Inflammation and Itch Response Are Independently Regulated by Distinct Nociceptor Subsets](https://www.cell.com/immunity/fulltext/S1074-7613(26)00131-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761326001317%3Fshowall%3Dtrue)”. Immunity. doi:https://doi.org/10.1016/j.immuni.2026.03.020 - add\_circle do\_not\_disturb\_on Abstract - [ picture\_as\_pdfImmunity\_PIIS107476132600...](/sites/g/files/omnuum8911/files/2026-07/Immunity_PIIS1074761326001317.pdf) Common dermatological disorders are characterized by inflammation and severe itching, which represent a significant clinical challenge. The mechanisms by which nociceptive sensory neurons (nociceptors) integrate peripheral signals to modulate inflammation... - [ picture\_as\_pdfImmunity\_PIIS107476132600...](/sites/g/files/omnuum8911/files/2026-07/Immunity_PIIS1074761326001317.pdf) Ya-Hsuan Ho, Giacomo Bregni, Marco Stazi, Paola Peinado, Pei-Hsing Chen, Claudio Ballabio, Victoire Boulat, Shree Vadera, Yilin Guan, Zhikai Liu, Alicia Alonso de la Vega, Li Wang, Chao-Chi Ho, Henrique Veiga-Fernandes, Julian Downward, Min-Shu Hsieh, Maksym V. Kopanitsa, George Kassiotis, Christoforos Tsantoulas, Michael S. Schappe, Michael-Bogdan Margineanu, Dinis Pedro Calado, Isaac M. Chiu, Charles Swanton, Jin-Shing Chen, and Leanne Li. 2026. “[Nociceptive Innervation Limits Tertiary Lymphoid Structures to Promote Lung Cancer](https://www.cell.com/cell/fulltext/S0092-8674(26)00505-2?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867426005052%3Fshowall%3Dtrue)”. Cell. doi:https://doi.org/10.1016/j.cell.2026.04.038 Ya-Hsuan Ho, Giacomo Bregni, Marco Stazi, Paola Peinado, Pei-Hsing Chen, Claudio Ballabio, Victoire Boulat, Shree Vadera, Yilin Guan, Zhikai Liu, Alicia Alonso de la Vega, Li Wang, Chao-Chi Ho, Henrique Veiga-Fernandes, Julian Downward, Min-Shu Hsieh, Maksym V. Kopanitsa, George Kassiotis, Christoforos Tsantoulas, Michael S. Schappe, Michael-Bogdan Margineanu, Dinis Pedro Calado, Isaac M. Chiu, Charles Swanton, Jin-Shing Chen, and Leanne Li. 2026. “[Nociceptive Innervation Limits Tertiary Lymphoid Structures to Promote Lung Cancer](https://www.cell.com/cell/fulltext/S0092-8674(26)00505-2?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867426005052%3Fshowall%3Dtrue)”. Cell. doi:https://doi.org/10.1016/j.cell.2026.04.038 - add\_circle do\_not\_disturb\_on Abstract - [ picture\_as\_pdfCell\_PIIS0092867426005052...](/sites/g/files/omnuum8911/files/2026-07/Cell_PIIS0092867426005052.pdf) Sensory innervation regulates lung physiology and pathology, but its role in lung cancer is poorly understood. We show that lung adenocarcinoma (LUAD) progression locally amplifies nociceptive sensory innervation and activation, which drives the release... - [ picture\_as\_pdfCell\_PIIS0092867426005052...](/sites/g/files/omnuum8911/files/2026-07/Cell_PIIS0092867426005052.pdf) Larissa Staurengo-Ferrari, Calvin Wong, and Isaac M. Chiu. 2026. “[Neuroimmune Interferon Signals Sustain Arthritis Pain](https://www.nature.com/articles/s41593-026-02251-x)”. Nature Neuroscience. doi:https://doi.org/10.1038/s41593-026-02251-x Larissa Staurengo-Ferrari, Calvin Wong, and Isaac M. Chiu. 2026. “[Neuroimmune Interferon Signals Sustain Arthritis Pain](https://www.nature.com/articles/s41593-026-02251-x)”. Nature Neuroscience. doi:https://doi.org/10.1038/s41593-026-02251-x - [ picture\_as\_pdfNature\_Neuro\_s41593-026-0...](/sites/g/files/omnuum8911/files/2026-07/Nature_Neuro_s41593-026-02251-x.pdf) - [ picture\_as\_pdfNature\_Neuro\_s41593-026-0...](/sites/g/files/omnuum8911/files/2026-07/Nature_Neuro_s41593-026-02251-x.pdf) Xin Jiang, Laure Schaeffer, Divya Patni, Tommaso Russo, Chao-Zong Lee, Corey Aguilar, Christine Marques, Karen Jansen-West, Marian Hruska-Plochan, Ananya Ray-Soni, Su Min Lim, Aaron Held, Mei Yue, Paula Castellanos Otero, Sandeep Aryal, Hortense D A M Beaussant, Himanish Basu, Hiro Takakuwa, Lillian M Daughrity, Nandini Ramesh, Paulo Da Costa, Ana Rita A A Quadros, Matthew Nolan, Charles Jourdan F Reyes, Hayden Wheeler, Laura C Moran, Grant Griesman, Benjamin Wymann, Bianca A Trombetta, Emma Sofia Lopez-De-Silanes, Michael Canori, Gopinath Krishnan, Yasmim Vieira Souza Da Silva, Gilbert Eriani, Mark W Albers, Steven E Arnold, Yuyu Song, Ankur Jain, Isaac M Chiu, Yong-Jie Zhang, Fen-Biao Gao, Brian J Wainger, Magdalini Polymenidou, Leonard Petrucelli, Franck Martin, and Clotilde Lagier-Tourenne. 2026. “[Blocking RAN Translation Without Altering Repeat RNAs Rescues C9ORF72-Related ALS and FTD Phenotypes](https://www.science.org/doi/10.1126/science.adv2600)”. Science. doi:10.1126/science.adv2600 Xin Jiang, Laure Schaeffer, Divya Patni, Tommaso Russo, Chao-Zong Lee, Corey Aguilar, Christine Marques, Karen Jansen-West, Marian Hruska-Plochan, Ananya Ray-Soni, Su Min Lim, Aaron Held, Mei Yue, Paula Castellanos Otero, Sandeep Aryal, Hortense D A M Beaussant, Himanish Basu, Hiro Takakuwa, Lillian M Daughrity, Nandini Ramesh, Paulo Da Costa, Ana Rita A A Quadros, Matthew Nolan, Charles Jourdan F Reyes, Hayden Wheeler, Laura C Moran, Grant Griesman, Benjamin Wymann, Bianca A Trombetta, Emma Sofia Lopez-De-Silanes, Michael Canori, Gopinath Krishnan, Yasmim Vieira Souza Da Silva, Gilbert Eriani, Mark W Albers, Steven E Arnold, Yuyu Song, Ankur Jain, Isaac M Chiu, Yong-Jie Zhang, Fen-Biao Gao, Brian J Wainger, Magdalini Polymenidou, Leonard Petrucelli, Franck Martin, and Clotilde Lagier-Tourenne. 2026. “[Blocking RAN Translation Without Altering Repeat RNAs Rescues C9ORF72-Related ALS and FTD Phenotypes](https://www.science.org/doi/10.1126/science.adv2600)”. Science. doi:10.1126/science.adv2600 - add\_circle do\_not\_disturb\_on Abstract - [ picture\_as\_pdfScience.pdf](/sites/g/files/omnuum8911/files/2026-07/science.adv2600.pdf) GGGGCC (G4C2) repeat expansion in *C9ORF72* is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Toxicity is thought to result from the accumulation of either repeat RNAs and/or dipeptide repeat proteins... - [ picture\_as\_pdfScience.pdf](/sites/g/files/omnuum8911/files/2026-07/science.adv2600.pdf) ### 2025 Duygu Payzin-Dogru, Tim Froitzheim, Steven J Blair, Siddhartha G Jena, Hani Singer, Julia C Paoli, Ryan T Kim, Emil Kriukov, Sarah E Wilson, Renzhi Hou, Aaron M Savage, Victor Cat, Louis Cammarata V, S Y Celeste Wu, Vivien Bothe, Burcu Erdogan, Shifa Hossain, Noah Lopez, Julia Losner, Juan Velazquez Matos, Sangwon Min, Sebastian Böhm, Anthony E Striker, Kelly E Dooling, Adam H Freedman, Bobby Groves, Benjamin Tajer, Glory Kalu, Eric Wynn, Alan Y L Wong, Nadia Fröbisch, Petr Baranov, Maksim Plikus V, Jason D Buenrostro, Brian J Haas, Isaac M Chiu, Timothy B Sackton, and Jessica L Whited. 2025. “[Adrenergic Signaling Coordinates Distant and Local Responses to Amputation in Axolotl](https://pmc.ncbi.nlm.nih.gov/articles/PMC12713581/)”. Cell. doi:https://doi.org/10.1016/j.cell.2025.09.025 Duygu Payzin-Dogru, Tim Froitzheim, Steven J Blair, Siddhartha G Jena, Hani Singer, Julia C Paoli, Ryan T Kim, Emil Kriukov, Sarah E Wilson, Renzhi Hou, Aaron M Savage, Victor Cat, Louis Cammarata V, S Y Celeste Wu, Vivien Bothe, Burcu Erdogan, Shifa Hossain, Noah Lopez, Julia Losner, Juan Velazquez Matos, Sangwon Min, Sebastian Böhm, Anthony E Striker, Kelly E Dooling, Adam H Freedman, Bobby Groves, Benjamin Tajer, Glory Kalu, Eric Wynn, Alan Y L Wong, Nadia Fröbisch, Petr Baranov, Maksim Plikus V, Jason D Buenrostro, Brian J Haas, Isaac M Chiu, Timothy B Sackton, and Jessica L Whited. 2025. “[Adrenergic Signaling Coordinates Distant and Local Responses to Amputation in Axolotl](https://pmc.ncbi.nlm.nih.gov/articles/PMC12713581/)”. Cell. doi:https://doi.org/10.1016/j.cell.2025.09.025 - add\_circle do\_not\_disturb\_on Abstract - [ descriptionPublisher's Version](https://linkinghub.elsevier.com/retrieve/pii/S0092-8674(25)01125-0) - [ picture\_as\_pdfCell.pdf](/sites/g/files/omnuum8911/files/2026-07/nihms-2115848_0.pdf) Many species regenerate lost body parts following amputation. Most limb regeneration research has focused on the immediate injury site. Meanwhile, body-wide injury responses remain largely unexplored but may be critical for regeneration. Here, we... - [ descriptionPublisher's Version](https://linkinghub.elsevier.com/retrieve/pii/S0092-8674(25)01125-0) - [ picture\_as\_pdfCell.pdf](/sites/g/files/omnuum8911/files/2026-07/nihms-2115848_0.pdf) Deepika Sharma, Ankit Malik, Veronica Locher, Shaina McGrath, Sarah Zabala, Hardik Grover, Cezary Ciszewski, Li Chen, Daping Yang, Isaac M Chiu, and Bana Jabri. 2025. “[A Myeloid Tet2-IL-1β Axis Modulates Intestinal Inflammation by Restricting Catecholaminergic Stimulation of Enterochromaffin Cell Differentiation](https://www.cell.com/immunity/fulltext/S1074-7613(25)00467-4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761325004674%3Fshowall%3Dtrue)”. Immunity. doi:https://doi.org/10.1016/j.immuni.2025.10.012 Deepika Sharma, Ankit Malik, Veronica Locher, Shaina McGrath, Sarah Zabala, Hardik Grover, Cezary Ciszewski, Li Chen, Daping Yang, Isaac M Chiu, and Bana Jabri. 2025. “[A Myeloid Tet2-IL-1β Axis Modulates Intestinal Inflammation by Restricting Catecholaminergic Stimulation of Enterochromaffin Cell Differentiation](https://www.cell.com/immunity/fulltext/S1074-7613(25)00467-4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761325004674%3Fshowall%3Dtrue)”. Immunity. doi:https://doi.org/10.1016/j.immuni.2025.10.012 - add\_circle do\_not\_disturb\_on Abstract - [ picture\_as\_pdfImmunity.pdf](/sites/g/files/omnuum8911/files/2026-07/Immunity_PIIS1074761325004674.pdf) Deciphering multicellular interactions is essential to understanding immune-mediated diseases. Myeloid cells can coordinate inflammatory responses and are central to immune crosstalk with neuronal, epithelial, and stromal cells. Here, we show that myeloid... - [ picture\_as\_pdfImmunity.pdf](/sites/g/files/omnuum8911/files/2026-07/Immunity_PIIS1074761325004674.pdf) Pavitha Parathan, Kelly Tran, Liam Neil, Tao Tan, Annalisa L E Carli, Yang Liao, Dmitri Mouradov, Jessica Da Gama Duarte, Anne Huber, Bhupinder Pal, Peter Gibbs, Oliver M Sieber, Isaac M Chiu, Conor J Kearney, Wei Shi, John M Mariadason, David S Williams, Michael Buchert, and Lisa A Mielke. 2025. “[Sensory Neuropeptide CGRP and Its Co-Receptor RAMP1 Drive Tumour Cell Growth in Gastrointestinal Cancers](https://pmc.ncbi.nlm.nih.gov/articles/PMC12557745/)”. BMJ Oncology. doi:10.1136/bmjonc-2025-000842 Pavitha Parathan, Kelly Tran, Liam Neil, Tao Tan, Annalisa L E Carli, Yang Liao, Dmitri Mouradov, Jessica Da Gama Duarte, Anne Huber, Bhupinder Pal, Peter Gibbs, Oliver M Sieber, Isaac M Chiu, Conor J Kearney, Wei Shi, John M Mariadason, David S Williams, Michael Buchert, and Lisa A Mielke. 2025. “[Sensory Neuropeptide CGRP and Its Co-Receptor RAMP1 Drive Tumour Cell Growth in Gastrointestinal Cancers](https://pmc.ncbi.nlm.nih.gov/articles/PMC12557745/)”. BMJ Oncology. doi:10.1136/bmjonc-2025-000842 - add\_circle do\_not\_disturb\_on Abstract - [ descriptionPublisher's Version](https://bmjoncology.bmj.com/content/4/1/e000842) - [ picture\_as\_pdfBMJOncology.pdf](/sites/g/files/omnuum8911/files/2026-07/bmjonc-4-1.pdf) **Objective:** The gastrointestinal (GI) tract is densely innervated, forming a critical network that secretes neuropeptides essential for gut function. Tumour cells are highly adaptive and exploit their microenvironment, including nerves, to support and... - [ descriptionPublisher's Version](https://bmjoncology.bmj.com/content/4/1/e000842) - [ picture\_as\_pdfBMJOncology.pdf](/sites/g/files/omnuum8911/files/2026-07/bmjonc-4-1.pdf) [ More arrow\_circle\_right ](/publications)