1. Recent Publications

    An Intestinal Organ Culture System Uncovers a Role for the Nervous System in Microbe-Immune Crosstalk.
    Yissachar N, Zhou Y, Ung L, Lai NY, Mohan JF, Ehrlicher A, Weitz DA, Kasper DL, Chiu IM*, Mathis D*, Benoist C*.
    Cell. 2017 Mar 9;168(6):1135-1148.e12. doi: 10.1016/j.cell.2017.02.009. *Corresponding authors.

  1. Infection, Pain, and Itch.
    Chiu IM.
    Neurosci Bull. 2017 Jan 31. doi: 10.1007/s12264-017-0098-1.

  1. Sensory neuron regulation of gastrointestinal inflammation and bacterial host defence.
    Lai NY, Mills K, Chiu IM.
    J Intern Med. 2017 Feb 2. doi: 10.1111/joim.12591.

  1. Bacterial Signaling to the Nervous System through Toxins and Metabolites.
    Yang, NJ., Chiu IM.
    J Mol Biol. 2017 Mar 10;429(5):587-605. doi: 10.1016/j.jmb.2016.12.023.

  1. Nociceptor sensory neuron-immune interactions in pain and inflammation
    Pinho-Ribeiro FA, Verri Jr, WA, and Chiu IM.
    Trends Immunol. 2017 Jan;38(1):5-19. doi: 10.1016/j.it.2016.10.001

  1. Pain and Itch: Beneficial or Harmful to Antimicrobial Defense?
    Baral P, Mills K, Pinho-Ribeiro FA, Chiu IM.
    Cell Host Microbe. 2016 Jun 8;19(6):755-9. doi: 10.1016/j.chom.2016.05.010.

  1. Pain and infection: pathogen detection by nociceptors.
    Chiu IM, Pinho-Ribeiro FA, Woolf CJ.
    Pain. 2016 Jun;157(6):1192-3. doi: 10.1097/j.pain.0000000000000559.

  1. Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation.
    Talbot S, Abdulnour RE, Burkett PR, Lee S, Cronin SJ, Pascal MA, Laedermann C, Foster SL, Tran JV, Lai N, Chiu IM, Ghasemlou N, DiBiase M, Roberson D, Von Hehn C, Agac B, Haworth O, Seki H, Penninger JM, Kuchroo VK, Bean BP, Levy BD, Woolf CJ. Neuron. 2015 Jul 15;87(2):341-54. doi: 10.1016/j.neuron.2015.06.007. Epub 2015 Jun 25.
    Free PMC Article

  1. CD11b+Ly6G- myeloid cells mediate mechanical inflammatory pain hypersensitivity.
    Ghasemlou N, Chiu IM, Julien JP, Woolf CJ.
    Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):E6808-17. doi: 10.1073/pnas.1501372112. Epub 2015 Nov 23.

  1. Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts.
    Wainger BJ, Buttermore ED, Oliveira JT, Mellin C, Lee S, Saber WA, Wang AJ, Ichida JK, Chiu IM, Barrett L, Huebner EA, Bilgin C, Tsujimoto N, Brenneis C, Kapur K, Rubin LL, Eggan K, Woolf CJ. Nat Neurosci. 2015 Jan;18(1):17-24. doi: 10.1038/nn.3886. Epub 2014 Nov 24.

  1. Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity.
    Chiu IM, Barrett LB, Williams EK, Strochlic DE, Lee S, Weyer AD, Lou S, Bryman G, Roberson DP, Ghasemlou N, Piccoli C, Ahat E, Wang V, Cobos EJ, Stucky CL, Ma Q, Liberles SD, Woolf C.Elife. 2014 Dec 19;3. doi: 10.7554/eLife.04660.

  1. Bacteria activate sensory neurons that modulate pain and inflammation.
    Chiu IM, Heesters BA, Ghasemlou N, Von Hehn CA, Zhao F, Tran J, Wainger B, Strominger A, Muralidharan S, Horswill AR, Bubeck Wardenburg J, Hwang SW, Carroll MC, Woolf CJ.Nature. 2013 Sep 5; 501(7465):52-7.

    Featured in News&Views: Nature. 2013 Sep 5;501(7465):43-4. doi: 10.1038/nature12550. Epub 2013 Aug 21.

  1. A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model.
    Chiu IM, Morimoto ET, Goodarzi H, Liao JT, O'Keeffe S, Phatnani HP, Muratet M, Carroll MC, Levy S, Tavazoie S, Myers RM, Maniatis T. Cell Rep. 2013 Jul 25; 4(2):385-401.

  1. Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology.
    Chiu IM, von Hehn CA, Woolf CJ. Nat Neurosci. 2012 Aug; 15(8):1063-7.

  2. Pre 2012

  1. Blockade of self-reactive IgM significantly reduces injury in a murine model of acute myocardial infarction.
    Haas MS, Alicot EM, Schuerpf F, Chiu I, Li J, Moore FD, Carroll MC. Cardiovasc Res. 2010 Sep 1; 87(4):618-27.

  1. Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.
    Chiu IM, Phatnani H, Kuligowski M, Tapia JC, Carrasco MA, Zhang M, Maniatis T, Carroll MC. Proc Natl Acad Sci U S A. 2009 Dec 8; 106(49):20960-5.

  1. T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS
    Chiu IM, Chen A, Zheng Y, Kosaras B, Tsiftsoglou SA, Vartanian TK, Brown RH, Carroll MC. Proc Natl Acad Sci U S A. 2008 Nov 18; 105(46):17913-8.

  1. Suppression of complement regulatory protein C1 inhibitor in vascular endothelial activation by inhibiting vascular cell adhesion molecule-1 action.
    Zhang H, Qin G, Liang G, Li J, Chiu I, Barrington RA, Liu D. Biochem Biophys Res Commun. 2007 Jul 13; 358(4):1120-7.

  1. Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis.
    Ma Y, Li J, Chiu I, Wang Y, Sloane JA, Lü J, Kosaras B, Sidman RL, Volpe JJ, Vartanian T. J Cell Biol. 2006 Oct 23; 175(2):209-15.

  1. Anti-apoptotic role for C1 inhibitor in ischemia/reperfusion-induced myocardial cell injury.
    Fu J, Lin G, Wu Z, Ceng B, Wu Y, Liang G, Qin G, Li J, Chiu I, Liu D. Biochem Biophys Res Commun. 2006 Oct 20; 349(2):504-12.

  1. Identification of the target self-antigens in reperfusion injury.
    Zhang M, Alicot EM, Chiu I, Li J, Verna N, Vorup-Jensen T, Kessler B, Shimaoka M, Chan R, Friend D, Mahmood U, Weissleder R, Moore FD, Carroll MC. J Exp Med. 2006 Jan 23; 203(1):141-52.

  1. Identification of a specific self-reactive IgM antibody that initiates intestinal ischemia/reperfusion injury.
    Zhang M, Austen WG, Chiu I, Alicot EM, Hung R, Ma M, Verna N, Xu M, Hechtman HB, Moore FD, Carroll MC. Proc Natl Acad Sci U S A. 2004 Mar 16; 101(11):3886-91.

  1. MLL 5 protein forms intranuclear foci, and overexpression inhibits cell cycle progression.
    Deng LW, Chiu I, Strominger JL. Proc Natl Acad Sci U S A. 2004 Jan 20; 101(3):757-62.

  1. The human natural killer cell immune synapse.
    Davis DM, Chiu I, Fassett M, Cohen GB, Mandelboim O, Strominger JL. Proc Natl Acad Sci U S A. 1999 Dec 21; 96(26):15062-7.

  1. Trafficking of spontaneously endocytosed MHC proteins.
    Chiu I, Davis DM, Strominger JL.Proc Natl Acad Sci U S A. 1999 Nov 23; 96(24):13944-9.

  1. Impaired spontaneous endocytosis of HLA-G.
    Davis DM, Reyburn HT, Pazmany L, Chiu I, Mandelboim O, Strominger JL.Eur J Immunol. 1997 Oct; 27(10):2714-9.