1. Recent Publications

    The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation.
    Wallrapp A, Riesenfeld SJ, Burkett PR, Abdulnour RE, Nyman J, Dionne D, Hofree M, Cuoco MS, Rodman C, Farouq D, Haas BJ, Tickle TL, Trombetta JJ, Baral P, Klose CSN, Mahlakoiv T, Artis D, Rozenblatt-Rosen O, Chiu IM, Levy BD, Kowalczyk MS, Regev A, and Kuchroo VK.
    Nature. 2017 Sep 21;549(7672):351-356. doi: 10.1038/nature24029.

  1. An Intestinal Organ Culture System Uncovers a Role for the Nervous System in Microbe-Immune Crosstalk.
    Yissachar N, Zhou Y, Ung L, Lai NY, Mohan JF, Ehrlicher A, Weitz DA, Kasper DL, Chiu IM*, Mathis D*, and Benoist C*.
    Cell. 2017 Mar 9;168(6):1135-1148.e12. doi: 10.1016/j.cell.2017.02.009. *Co-corresponding authors.

  1. Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation.
    Talbot S, Abdulnour RE, Burkett PR, Lee S, Cronin SJ, Pascal MA, Laedermann C, Foster SL, Tran JV, Lai N, Chiu IM, Ghasemlou N, DiBiase M, Roberson D, Von Hehn C, Agac B, Haworth O, Seki H, Penninger JM, Kuchroo VK, Bean BP, Levy BD, and Woolf CJ.
    Neuron. 2015 Jul 15;87(2):341-54. doi: 10.1016/j.neuron.2015.06.007. Epub 2015 Jun 25.

  1. CD11b+Ly6G- myeloid cells mediate mechanical inflammatory pain hypersensitivity.
    Ghasemlou N, Chiu IM, Julien JP, and Woolf CJ.
    Proceedings of National Academy Sciences U S A. 2015 Dec 8;112(49):E6808-17. doi: 10.1073/pnas.1501372112. Epub 2015 Nov 23.

  1. Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts.
    Wainger BJ, Buttermore ED, Oliveira JT, Mellin C, Lee S, Saber WA, Wang AJ, Ichida JK, Chiu IM, Barrett L, Huebner EA, Bilgin C, Tsujimoto N, Brenneis C, Kapur K, Rubin LL, Eggan K, and Woolf CJ.
    Nature Neuroscience. 2015 Jan;18(1):17-24. doi: 10.1038/nn.3886. Epub 2014 Nov 24.

  1. Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity.
    Chiu IM*, Barrett LB, Williams EK, Strochlic DE, Lee S, Weyer AD, Lou S, Bryman G, Roberson DP, Ghasemlou N, Piccoli C, Ahat E, Wang V, Cobos EJ, Stucky CL, Ma Q, Liberles SD, and Woolf CJ*.
    ELife. 2014 Dec 19;3. doi: 10.7554/eLife.04660. *Co-corresponding authors.

  1. Bacteria activate sensory neurons that modulate pain and inflammation.
    Chiu IM, Heesters BA, Ghasemlou N, Von Hehn CA, Zhao F, Tran J, Wainger B, Strominger A, Muralidharan S, Horswill AR, Bubeck Wardenburg J, Hwang SW, Carroll MC, and Woolf CJ.
    Nature. 2013 Sep 5; 501(7465):52-7. doi: 10.1038/nature12479.

    Featured in News&Views: Nature. 2013 Sep 5;501(7465):43-4. doi:10.1038/nature12550. Epub 2013 Aug 21.

  1. A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model.
    Chiu IM, Morimoto ET, Goodarzi H, Liao JT, O'Keeffe S, Phatnani HP, Muratet M, Carroll MC, Levy S, Tavazoie S, Myers RM, and Maniatis T.
    Cell Reports. 2013 Jul 25; 4(2):385-401. doi: 10.1016/j.celrep.2013.06.018.

    Review Articles

  1. Neuro-immune interactions in inflammation and host defense: Implications for transplantation.
    Chavan SS, Ma, P, and Chiu IM.
    Am J. Transplantation 2017 Sep 23. doi: 10.1111/ajt.14515.

  1. Neuro-immune interactions in allergic diseases: novel targets for therapeutics.
    Voisin, T, Bouvier, A, and Chiu IM.
    International Immunology. 2017 Jun 1;29(6):247-261. doi: 10.1093/intimm/dxx040.

  1. Bacterial Signaling to the Nervous System through Toxins and Metabolites.
    Yang NJ and Chiu IM.
    J. Molecular Biology. 2017 Mar 10;429(5):587-605. doi: 10.1016/j.jmb.2016.12.023.

  1. Sensory neuron regulation of gastrointestinal inflammation and bacterial host defence.
    Lai NY, Mills K, and Chiu IM.
    J. Internal Medicine. 2017 Feb 2. doi: 10.1111/joim.12591.

  1. Nociceptor sensory neuron-immune interactions in pain and inflammation
    Pinho-Ribeiro FA, Verri Jr, WA, and Chiu IM.
    Trends in Immunology. 2017 Jan;38(1):5-19. doi: 10.1016/j.it.2016.10.001

  1. Infection, Pain, and Itch.
    Chiu IM.
    Neuroscience Bulletin. 2017 Jan 31. doi: 10.1007/s12264-017-0098-1.

  1. Pain and Itch: Beneficial or Harmful to Antimicrobial Defense?
    Baral P, Mills K, Pinho-Ribeiro FA, and Chiu IM.
    Cell Host & Microbe. 2016 Jun 8;19(6):755-9. doi: 10.1016/j.chom.2016.05.010.

  1. Pain and infection: pathogen detection by nociceptors.
    Chiu IM, Pinho-Ribeiro FA, and Woolf CJ.
    Pain. 2016 Jun;157(6):1192-3. doi: 10.1097/j.pain.0000000000000559.

    Pre 2013 Publications

  1. Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology.
    Chiu IM*, von Hehn CA*, and Woolf CJ.
    Nature Neuroscience. 2012 Aug; 15(8):1063-7. doi: 10.1038/nn.3144. *These authors contributed equally.

  1. Blockade of self-reactive IgM significantly reduces injury in a murine model of acute myocardial infarction.
    Haas MS, Alicot EM, Schuerpf F, Chiu I, Li J, Moore FD, and Carroll MC.
    Cardiovascular Research. 2010 Sep 1; 87(4):618-27.

  1. Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.
    Chiu IM, Phatnani H, Kuligowski M, Tapia JC, Carrasco MA, Zhang M, Maniatis T, and Carroll MC.
    Proceedings of National Academy Sciences U S A. 2009 Dec 8; 106(49):20960-5.

  1. T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS
    Chiu IM, Chen A, Zheng Y, Kosaras B, Tsiftsoglou SA, Vartanian TK, Brown RH, and Carroll MC.
    Proceedings of National Academy Sciences U S A. 2008 Nov 18; 105(46):17913-8.

  1. Suppression of complement regulatory protein C1 inhibitor in vascular endothelial activation by inhibiting vascular cell adhesion molecule-1 action.
    Zhang H, Qin G, Liang G, Li J, Chiu I, Barrington RA, and Liu D.
    Biochem Biophys Res Commun. 2007 Jul 13; 358(4):1120-7.

  1. Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis.
    Ma Y, Li J, Chiu I, Wang Y, Sloane JA, Lü J, Kosaras B, Sidman RL, Volpe JJ, and Vartanian T.
    J Cell Biology. 2006 Oct 23; 175(2):209-15.

  1. Anti-apoptotic role for C1 inhibitor in ischemia/reperfusion-induced myocardial cell injury.
    Fu J, Lin G, Wu Z, Ceng B, Wu Y, Liang G, Qin G, Li J, Chiu I, and Liu D.
    Biochem Biophys Res Commun. 2006 Oct 20; 349(2):504-12.

  1. Identification of the target self-antigens in reperfusion injury.
    Zhang M, Alicot EM, Chiu I, Li J, Verna N, Vorup-Jensen T, Kessler B, Shimaoka M, Chan R, Friend D, Mahmood U, Weissleder R, Moore FD, and Carroll MC.
    J Experimental Medicine. 2006 Jan 23; 203(1):141-52.

  1. Identification of a specific self-reactive IgM antibody that initiates intestinal ischemia/reperfusion injury.
    Zhang M, Austen WG, Chiu I, Alicot EM, Hung R, Ma M, Verna N, Xu M, Hechtman HB, Moore FD, and Carroll MC.
    Proceedings of National Academy Sciences U S A. 2004 Mar 16; 101(11):3886-91.

  1. MLL 5 protein forms intranuclear foci, and overexpression inhibits cell cycle progression.
    Deng LW, Chiu I, and Strominger JL.
    Proceedings of National Academy Sciences U S A. 2004 Jan 20; 101(3):757-62.

  1. The human natural killer cell immune synapse.
    Davis DM, Chiu I, Fassett M, Cohen GB, Mandelboim O, and Strominger JL.
    Proceedings of National Academy Sciences U S A. 1999 Dec 21; 96(26):15062-7.

  1. Trafficking of spontaneously endocytosed MHC proteins.
    Chiu I*, Davis DM*, and Strominger JL.
    Proceedings of National Academy Sciences U S A. 1999 Nov 23; 96(24):13944-9. *These authors contributed equally.

  1. Impaired spontaneous endocytosis of HLA-G.
    Davis DM, Reyburn HT, Pazmany L, Chiu I, Mandelboim O, and Strominger JL.
    Eur J. Immunology. 1997 Oct; 27(10):2714-9.